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Weeks 1 through 4 The initial month focuses on tolerability

Because the incidence of AEs was greatest during dose escalation, the disparity in total years of exposure between the two trials could potentially dilute the reported rate of AEs in PIONEER 3 compared with PIONEER 12

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While tirzepatide uses GIP to enhance insulin sensitivity and metabolic efficiency, retatrutide adds direct fat-burning stimulation through glucagon

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