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Thus, Functional Analytic Psychotherapy (Acceptance and Commitment Therapy), targeting psychological flexibility and social connectedness as key mechanisms of change, may be useful in treating women with lipedema.28 Furthermore, on a standardized measure of health-related quality of life, anxiety or depression was found in 42% of individuals with lipedema, and a history of eating disorders particularly anorexia and binge eating is also common, being identified in 74% of 100 participants in another study.15 The impact of psychological distress in this condition can be vastly underestimated, and early diagnosis and treatment may help reduce the impact of lipedema on mental health.24 Imaging findings Imaging modalities have become essential adjuncts in the evaluation of suspected lipedema, particularly when the clinical picture overlaps with other conditions

Interestingly, NKCC1 KO mice also showed reduced satiation control to ad libitum feeding before developing overweight and a MetS-like phenotype (Rathod et al., 2023), consistent with the hypothesis that islets hormones participate in the control of food/energy intake (Woods et al., 2006)

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