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Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines

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PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC 50 of 4.8 nM in A549 cell line, sensitive to oncogenic mutations (no activity to Y1230C mutant)

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In addition, mitochondrial shrinkage and increased membrane density were observed, indicating that SAL induces ferroptosis and exacerbates neurotoxicity in both in vivo and in vitro PD models