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Mice were treated with cotadutide, liraglutide, g1437 or liraglutide+g1437 at equimolar dosing (10 nmol/kg, SC, QD for 42 days) compared to vehicle

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Risks/ disadvantages of GLP-1 agonists: Nausea and vomiting (far less likely when starting on a very low dose and titrating up slowly) Diarrhoea Dizziness and tiredness Mild tachycardia (increased heart rate) Headaches Temporary itchiness /redness around injection sites Dry mouth/reduced salivary secretions Low blood sugar Rare but more serious side effects: Pancreatitis More serious gut side effects because of stagnated gut movement Medullary thyroid cancer Sudden kidney injury (usually because of reduced volume intake or vomiting) Worsening of diabetic retinopathy (diabetes related eye disease) Allergic reactions Gallbladder or biliary disease Depression and suicidal ideation Aspiration (food or liquid getting into lungs) during anaesthesia as the stomach empties more slowly- ideally the medication should be stopped for 2-4 weeks prior to elective surgery

Roughly 12 to 24 months

Through such effects, semaglutide also aids in reducing adipose tissue due to the forced mobilization of stored triglycerides for energy production