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Obesity 27 , 20052010 (2019)

By simultaneously activating GIP, GLP-1, and glucagon receptors, this powerful peptide produces synergistic metabolic effects that exceed what single or dual agonist medications can achieve

Current evidence does not support routine clinical use of GLP-1 medications specifically for alcohol cravings, and patients with alcohol use disorder should be referred to evidence-based treatments including behavioral interventions, mutual support groups, and FDA-approved pharmacotherapies such as naltrexone, acamprosate, and disulfiram

Initially developed for diabetes, they are now widely used for obesity treatment and are under investigation for a wide range of other conditions, from kidney and heart disease to addiction to dementia

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