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Hypoglycemia risk is low when GLP-1 receptor agonists are used as monotherapy due to their glucose-dependent mechanism of action

The weight loss trajectory typically shows initial results within the first month, with patients losing about 4% of body weight

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Despite this scale, no drug therapies have been approved to treat the condition

The GLP-1 shortage challenges are exacerbated by a lack of accurate, up-to-date, and accessible GLP-1 supply information

It remains to be investigated whether cardiovascular protective effects of GLP-1RAs can also be independent of the known effects on glucose metabolism