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In some patients, gastrointestinal side effects can be severe enough to lead to treatment discontinuation

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The initial TRIUMPH Phase 3 clinical development program is evaluating the safety and efficacy of retatrutide for the treatment of patients with obesity or overweight, moderate-to-severe OSA and obesity, and knee osteoarthritis pain across four global registrational trials

Each production lot is independently characterized using high-performance liquid chromatography (HPLC) and liquid chromatographymass spectrometry (LCMS) protocols