GLP-1 medications are highly regulated they go through years of clinical trials to collect sufficient data on the drugs safety and effectiveness before theyre approved for use
Potential new therapies to preserve lean muscle mass loss when used in combination with GLP-1 receptor agonist. Diabetes, Obesity and Metabolism
There is no scientific evidence supporting the effectiveness of these supplements for weight loss or blood sugar management." Kumar adds that GLP-1 supplements are "largely a marketing ploy to capitalize on the current cultural craze around weight loss medications." If they do have an effect, it's likely mild and "not effective enough to treat overweight and obesity," she explains
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32,33 Under physiological conditions, besides the paracrine secretion pathway in the gastrointestinal tract, most endogenous GLP-1 in circulation is locally deactivated by DPP-4 and the liver, 34 making it difficult to directly enter the CNS through the blood-brain barrier