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Abnormal neural progenitor cells differentiated from induced pluripotent stem cells partially mimicked development of TSC2 neurological abnormalities

The doses used in trials were around 500ug/kg, which means a 100kg person was receiving 50mg of the peptide daily. $50 million in research and development down the drain for a promising product that was no longer a viable pharmaceutical product

Kerbel, R.S

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Epitalon treatment reduced intracellular reactive oxygen species, decreased spindle defects and abnormal cortical granule distribution, and increased mitochondrial membrane potential and mitochondrial DNA copy number