ph of glutathione and endosomal pH-responsive hybrid vesicles fabricated by zwitterionic polymer block poly(l-aspartic acid) as a smart anticancer delivery platform Abib Mild Acidic pH Sheet

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Meanwhile, GSH preservation in cytosolic and mitochondrial fractions downregulates the expression of RIPK1, RIPK3, or MLKL, preventing necrosome formation 74,75

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doi: 10.1371/journal.pgen.1004488 11 Miljkovic-GacicIFerrellREPatrickALKammererCMBunkerCH

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Radiotherapy has been widely used in tumors such as skin, cervical, head-and-neck, laryngeal, nasopharyngeal, prostate, and breast cancer, however, many types of tumors, including glioblastoma, soft-tissue cancers as well as non-small cell lung cancer are less sensitive to radiotherapy due to their intrinsic resistance