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Semaglutide: The Breakthrough GLP-1 Semaglutide was the first GLP-1 drug to show double-digit percentage weight loss in large clinical trials

259 A double-blind placebo-controlled trial randomized 56 healthy individuals aged 2565 years with borderline cardiovascular disease (CVD) risk factors to receive placebo or 500 mg aged black garlic (providing 2.5 mg SAC) for 12 weeks

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Subsequent studies examined dose-response characteristics, receptor subtype contributions, and interactions with dopaminergic systems

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