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This is partly because the drugs effects occur so fast, and the number of mechanisms that too much of the drug in the system can disable

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3 Risk of pancreatitis has also been identified with taking GLP-1 agonists

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Due to tirzepatide's pharmacokinetic profile (peak concentration at approximately 24-48 hours and half-life of about 5 days), symptoms may persist for several days following a double dose, with effects potentially lasting longer than with shorter-acting GLP-1 receptor agonists

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In this same population there was a non-statistically significant increase in DVT and stroke in the patients randomized to tamoxifen

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