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Initial concerns were raised by an early, methodologically critiqued study and a series of case reports in which the majority of severe ocular complications presented as NAION [114, 115]

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5, 6 Furthermore, non-clinical and clinical studies have demonstrated increased satiety, reduced food intake and subsequent reductions in body weight following administration of GLP-1, 7, 8 leading to investigations into its potential for the treatment of obesity

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