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This dietary intervention trial received ethical approval from the Quadram Institute Bioscience Human Research Governance Committee (QIB01/2024) and the South East Scotland Research Ethics Committee (24/SS/0047) and is registered at ClinicalTrials.gov (NCT06518343)

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In vascular endothelial cells, they reduce the expression of TNF-, decrease the production of ROS, inhibit macrophage adhesion and activation, and protect against microvascular injury ( The finding that taking 31 minutes or longer to have breakfast after drug administration may predict the efficacy of oral semaglutide aligns with previous reports suggesting that prolonged fasting after administration increases the bioavailability of oral semaglutide (approximately 0.8% at 30 minutes, reaching a plateau of around 1.4% at 120 minutes) ( This study also demonstrated that a current history of both smoking and alcohol drinking is a predictor of the efficacy of oral semaglutide

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Tirzepatide HypoSpray therapy may be considered only when clinically appropriate, and it requires medical provider oversight from review through prescription access

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10.1016/j.ijbiomac.2025.145366 14 ChitkaraA.ManglaB.KumarP.JavedS.AhsanW.PopliH

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Cell Physiol Biochem 35:22232232 Wolf WM, Wattick RA, Kinkade ON, Olfert MD (2018) Geographical prevalence of polycystic ovary syndrome as determined by region and race/ethnicity

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