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In the present study, we found that cardiac mitophagy dysfunction induced by pressure overload can activate NLRP3 inflammasome, and lead to cardiac hypertrophy, and improving mitophagy by semaglutide could suppress the activation of NLRP3 inflammasome to alleviate cardiac hypertrophy

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hese findings suggested that FSH, as well as low estradiol, are potential targets for controlling fat accumulation and treating obesity