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The last 5 years have seen the emergence of efficacious peptide-based therapies for obesity treatment that target glucagon-like peptide-1 receptor (GLP-1R), either selectively or via co-activation with related receptors, such as the glucose-dependent insulinotropic polypeptide and/or glucagon receptors 1

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In 2021, a higher dose under the brand Wegovy received approval for chronic weight management in adults with obesity or in adults who are overweight with at least one weight-related condition