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Finally, considerable work in mice has described the tissue distribution of various arsenic metabolites

Targeting VEGF or hypoxia-inducible factor ( HIF-1 ) can help normalize the tumor blood vessels, promote drug delivery, improve tumor hypoxia and the immunosuppressive microenvironment 8 , and ultimately prevent or reverse drug resistance in breast cancer

The cells were harvested by centrifugation (4000 g, 10 min, 4 C)