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In fasted healthy normal weight patients, GLP-1 (7-36) amide injection reduced fMRI activity induced by food images, in all brain areas studied (amygdala, insula, caudate, NAc, orbitofrontal cortex, and putamen), compared to saline injection [43]

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The two peptides operate on entirely separate biological pathways: sermorelin targets the hypothalamic-pituitary-GH axis, while tirzepatide targets incretin receptors in the gut and brain

For those with type 2 diabetes, semaglutide may be needed to control blood sugar levels long-term

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