This increases cancer risk by two distinct mechanisms both through the promotion of chronic inflammation, and through inhibition of the acute inflammation that is important to halt tumorigenesis (anti-tumor immunity)
In vitro cellular senescence models (such as senescence models of human fibroblasts, hepatocytes, and nerve cells) are common tools for studying aging mechanisms and interventional drugs
Compared to healthy controls, they observed an upregulation in expression of angiogenic, inflammatory, and ECM remodeling gene markers (specifically MMP9, leptin, and HGF) (Al-Ghadban et al., 2023)
a-c , Analysis workflow of the roundness ( a ), smoothness ( b ), and invagination of nuclear envelope ( c ) of the nuclei in BJ fibroblasts
These components work synergistically to create shilajit's unique properties, particularly its ability to enhance nutrient absorption and bioavailability
Existing research is often hampered by small sample sizes, inadequate control groups (making comparisons difficult), and lack of publication in reputable journals
