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Introduction The microenvironment of the brain and central nervous system (CNS) is tightly regulated by the bloodbrain barrier (BBB), a physiological barrier between the peripheral blood circulation and the brain parenchyma (Engelhardt, 2003)

These are documented conventions, not validated or trial-derived doses

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In PD, the impact of Vit B12 deficiency can be mediated either by a direct impact of Vit B12 deficiency (Choi et al

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Most bacterial species in a healthy human microbiota belong to the genera Bacteroidetes and Firmicutes (232), whereas Actinobacteria , Proteobacteria , Fusobacteria , and Cyanobacteria , are less abundant (233)