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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

Compared with Ex-4, PEx-4 showed sustained release of Ex-4 into the CSF and plasma over 2 weeks (96)

SAVOR-TIMI, Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes MellitusThrombolysis in Myocardial Infarction 53

The NOS3 gene is located on chromosome 7q36.1 and is composed of 28 exons that generate four alternatively spliced mRNAs, each of which encode distinct protein isoforms

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