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Some usage-limiting properties of the designed peptides, including low selectivity and tumor cell uptake, poor tumor permeability and passing through the BBB in glioma cancer, and low plasma stability, can be improved by several techniques, such as intracellular delivery via the intracellular pathway, ligand-mediated tumor targeting, and nanoparticle-based drug delivery systems

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This analysis facilitated the evaluation of method parameters and confirmed that the variations between the techniques were normally distributed

9 That step funnels metabolites from branched-chain amino acids and fatty acid oxidation into the Krebs cycle

IKE has been described as a potent system (SLC7A11 inhibitor and ferroptosis inducer in several tumor models, primarily through depletion of intracellular cysteine/glutathione and accumulation of lipid peroxides [16] 19

Free Radic Biol Med (2021) 173:4151