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Direct reduction of TNF-alpha, IL-1beta, and IL-6
This disruption leads to neurological and hematological damage similar to that seen in N 2 O abuse, including posterior column lesions in the cervical and thoracic spinal cord, demyelination, or axonal injury of peripheral nerves
Clinical studies specifically evaluated markers of carbohydrate metabolism including fasting glucose, insulin levels, hemoglobin A1c (HbA1c), and insulin sensitivity indices