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doi: 10.1186/1471-230X-9-6 19 ClarkeG.McKernanD
Clinical trials at doses up to 40mg daily for 12 weeks have reported no serious adverse effects (Brendler & Williamson, 2019, Phytomedicine )
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However, growing evidence indicates that maternal gut microbiota can modulate nutrient absorption, metabolic conversion, and subsequent deposition into eggs, giving rise to the concept of a gut-egg axis. While microbial variability introduces additional complexity and inter-individual variation in enrichment outcomes, it also presents new opportunities for targeted intervention
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