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As shown in Supplementary Table 1, MMA was positively correlated with Creatinine, Blood urea nitrogen, and C-Peptide (r = 0.388, 0.293, and 0.229, respectively), while inversely correlated with High-density lipoprotein-cholesterol (HDL-C), eGFR, and B12 (r = -0.102, -0.405, and 0.291, respectively)

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Neuropeptide Y: complete amino acid sequence of the brain peptide