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Benzyl alcohol is a widely used pharmaceutical and laboratory preservative that disrupts bacterial cell membrane integrity and inhibits bacterial enzyme systems preventing microbial growth and maintaining the sterility of the reconstituted solution between uses
Although this form of thiamine deficiency, which we call gastrointestinal beriberi, is initially limited to the gastrointestinal system, it mostly progresses to systemic thiamine deficiency, often triggered by stresses of different etiologies
both drug candidates are in Phase 2 clinical trials that are expected to finish in the next 2 years
Bikle DD, Teichert A, Arnold L, Uchida Y, Elias P, Oda Y