In another hand, it is notable that the role of GH, if any, on the regulation of intratesticular IGF-I may not be significant, since GH receptor gene may not be expressed in the testis[134, 135] and GHI animals are fertile (normal steroidogenesis and spermatogenesis)[136, 137]
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on the other hand, bone-derived cells and metabolites are capable of crossing the BBB, thereby providing sustained immune regulation and neuroprotection