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These mechanisms include changes in microbial composition, immune activation, vagus nerve signaling, and the production of specific microbial neuroactive metabolites (197)

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J Biol Chem 267(31):2227722281 Pedrera L et al (2021) Ferroptotic pores induce Ca(2+) fluxes and ESCRT-III activation to modulate cell death kinetics

That breadth comes with a caveat more genes means more complexity in predicting all effects

Pro-caspase-1 is recruited to the complex upon inflammasome assembly and undergoes autoproteolytic cleavage to generate active caspase-1