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Preclinical studies further demonstrate that combining PPR with donepezil enhances therapeutic efficacy in AD rat models by improving synaptic plasticity, reducing oxidative stress, and ameliorating histopathological outcomes (36)

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10.1016/j.ocarto.2023.100433 212 ScanzelloC

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These analyses further strengthen the credibility of the associations described by multivariate regression analysis (Table 1)