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This selectivity has been confirmed in multiple species (rats, dogs, swine) and is attributed to ipamorelin having negligible activity on hypothalamic CRH neurons and pituitary lactotrophs

doi: 10.1016/j.jff.2011.12.005 [DOI] [Google Scholar] 49

Broadly, studies suggest GLP-1RAs exert their neuroprotective effects in the retina by mediating reduced glutamate excitotoxicity, decreased neuroinflammation, prevention of retinal ganglion cell (RGC) loss, promotion of vascular integrity, promotion of an anti-oxidative environment, and maintenance of glial cells (i.e

Unfortunately, its druggability is low

For many patients, the advantages outweigh the risks, especially when heart health is monitored carefully

Mnnist, S., Kontto, J., Kataja-Tuomola, M., Albanes, D., & Virtamo, J