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The GLP-1 receptor agonist market is growing rapidly, supported by rising obesity and diabetes prevalence, strong clinical outcomes, and increasing patient awareness

NICE guidance emphasises multicomponent interventions addressing diet, physical activity, and behavioural factors as first-line strategies

To date, the carnitine deficiency phenotype was observed in the context of (a) primary carnitine deficiency resulting from inactivating mutations in Octn2 gene, (b) secondary carnitine deficiency that may be caused by different metabolic abnormalities all ultimately leading to the loss of carnitine in the urine, and (c) patients with CKD undergoing hemodialysis and losing carnitine through the dialysis membrane (reviewed in ref

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10.1136/gut.29.8.1035 19 GaldovH.PolozsnyiZ.BreierA.imkoviM

Doi: 10.1677/joe.0.1650569