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Results typically begin at week 4 to 6 and compound through week 12: because MOTS-c works through mitochondrial gene expression and metabolic pathway activation rather than appetite suppression, the timeline is slower than GLP-1 therapies but produces different, complementary changes in metabolic function

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The drugs work by slowing the rate at which food moves through the stomach, which in rare cases may cause stomach paralysis or worsen an underlying condition, doctors told CNN

Mol Cell Proteomics 8(6):1338

Like so many issues in medicine, the TMAO issue is not as clear as one would want

BMJ 334 , 11591162 (2007)