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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis

Akaike (JP21zf0127001), and AMED CREST Grant Number 23gm161001h001 to T.S

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doi: 10.1002/rmv.2095 135 OkunoYMurataTSatoYMuramatsuHItoYWatanabeTet al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Ihnatowicz P., Drywie M., Wtor P., Wojsiat J