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Additionally, AhR signaling can alter microbial composition in the small intestine, acting as a crucial regulator of host-microbiota communication, thereby affecting host metabolism and modulating the immune system [54,55,56,57,58]

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The endogenous pathways for the degradation of histamine require either methylation (SAMe, Mg 2+ , and ATP) or mitochondrial ALDH

doi: 10.1016/j.autrev.2014.01.007 9 CayresL

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PMID 26013381