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Drug repurposing screening identifies tioconazole as an ATG4 inhibitor that suppresses autophagy and sensitizes cancer cells to chemotherapy

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This reframes the conversation entirely: GLP-1 medications are best understood not as a temporary course but as treatment for obesity as a chronic, relapsing disease much as one does not stop an antihypertensive once blood pressure normalizes

Apr 2008;44(4):303-314

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This review reconsiders the debated concept of food addiction in light of these pharmacological advances, drawing on neurobiological, societal, and emerging clinical perspectives