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Non-genetic mechanisms of therapeutic resistance in cancer

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Cell Stem Cell 19 , 2337 (2016)

15 likewise, lixisenatide was withdrawn from the US market as of January 1, 2023, for commercial reasons, rather than because of any safety or efficacy issues

Progestin and AdipoQ Receptor 4 (PAQR4), a member of the PAQR family localized in the Golgi apparatus, competitively binds to NRF2 when highly expressed, thereby enhancing the stability and nuclear translocation of NRF2