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Although more PD models are needed to validate whether PKM2 is a universal therapeutic target in PD, our results provide preliminary evidence that dimerizing PKM2 is a potential therapeutic approach to protect nigral dopaminergic neurons from oxidative damage

however, a quarter of the patients experienced dosing interruptions or dosage decreases during the study due to mecasermin shortages

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The most prominent interleukins (ILs) are IL-15, C-X-C motif ligand 16 (CXCL16), CXCL9, IL -17 and IL-1b [19, 20, 22,23,24]

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Mol Cell 76(5):838851.e5 Chen P, Li X, Zhang R, Liu S et al (2020) Combinative treatment of -elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation