Current research extrapolations suggest 1216 week treatment cycles followed by 48 week rest periods, though this is based on precautionary principle rather than evidence of receptor desensitization or tolerance development
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These include reducing xanthine oxidase (XOD) activity (24), regulating UA transporters to promote UA excretion (25), alleviating the inflammatory response (25,26) and reducing oxidative stress (27)
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15 Similarly, increased generation of NAD + via the KP in resting, aged or immune-challenged macrophages restores OXPHOS and homeostatic immune responses, whereas inhibition of de novo NAD + synthesis induces an increased inflammation-associated TCA-cycle metabolite succinate and elevated mitochondria-generated ROS, resulting in rising innate immune dysfunction in aging and age-associated diseases
Factors like your activity level, health goals, and personal schedule can influence timing
