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October 29, 2023

Before it was branded for weight loss, tirzepatide was already helping patients in another capacity

Pyridostigmine should be started (oral tablets) at least several hours before exposure to soman (8 hours in advance is preferred) , and discontinued upon exposure to the nerve gas, at which point atropine and pralidoxime are given at the first indication of exposure (see video in Figure 4)

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The mechanism is real, the evidence is consistent, and the dosing window is narrow