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Indeed, cells lacking SLC25A39/40 die upon inhibition of GSH synthesis by BSO treatment, an effect rescued by SLC25A39 cDNA (Fig

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"The association of elevated reactive oxygen species levels from neutrophils with low-grade inflammation in the elderly"

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Given that NAD + -depleting drugs exhibit anti-tumor potential due to their impact on DNA repair and inflammation, long-term boosting NAD + might increase the risk of driving tumor growth