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Introduction Seeing a drop of blood or a small bruise after a GLP1 shot can be surprising, especially if previous injections were perfectly clean

Table 2), it is likely that new weight-loss drugs will be marketed in the near-term future Table 1: Novel weight-loss drugs approved in the US Navigation Tips: First column and header row are frozen for easy reference Scroll horizontally and vertically to view all data Hover over rows to highlight them Use compact mode to fit more content Search to quickly find specific drugs Hover over truncated text to see full content Table 2: Late-stage anti-obesity drug development pipeline in the US 4

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An emerging concept is the ability for some of the IGF-I forms to bind directly to the ECM, potentially without the use of IGFBP stabilization

With the decrease of hyperinsulinemia, PDA stroma is thinner (Zhang et al., 2019)

N Engl J Med 375:311322 Hollander P, Gupta AK, Plodkowski R et al (2013) Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes