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Compared with EtOH-fed WT mice, KO mice were less susceptible to EtOH-induced deleterious effects, including body weight loss (reflected by less body weight gain), liver weight gain and hepatocyte damage (reflected by plasma ALT activity) (Table 1)

Ferroptosis is regulated by distinct molecular pathways and was shown to play an important role in degenerative and neoplastic diseases 26

Wang W, Wang Q, Qi X, Gurney M, Perry G, Volkow ND, et al