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Thus, several other P450 isoenzymes such as CYP1A2 and, to a lesser extent, CYP2B6 and CYP3A4 have the capacity to contribute to the microsomal oxidative metabolism of MDMA and MDA A recent study showed that while CYP2D6 was inhibited by MDMA, CYP1A2 increased its activity (Yubero-Lahoz et al., 2012)