Compared with IL12 mRNA-loaded liposomes, aerosolized exosomes demonstrated better mucus penetration 214,215 , resulting in notable immunogenicity
Funding This work has been partially funded by the Spanish Ministry of Health, Instituto de Salud Carlos III (ISCIII), FIS PI14-01962, and the Andalusian Government grant BIO177 (FEDER funds of European Commission)
In addition, TB-500, a synthetic part of thymosin beta-4, interacts directly with actin, a key protein for cell structure
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Aggressive dosing creates extreme caloric deficits
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