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Giles FJ, Cortes JE, Bivins C, Andreeff M , Talpaz M, Jolivet J, Kantarjian HM

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Key Takeaways Fundamentally different mechanisms: CJC-1295/Ipamorelin stimulate the pituitary to produce endogenous GH, while HGH (somatropin) introduces exogenous growth hormone directly Pituitary feedback preserved vs

N-terminal liver-expressed antimicrobial peptide 2 (LEAP2) region exhibits inverse agonist activity toward the ghrelin receptor