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doi: 10.3389/fphar.2014.00151 Received 27 May 2014 Accepted 10 June 2014 Published 01 July 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Richard Eugene Frye, Childrens Hospital Boston/Harvard Univerity, USA

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After 4 h, the microneedle tips had almost completely dissolved, and the drug concentration in the skin reached its peak, with a subcutaneous penetration depth of 200 m