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Other commonly reported side effects include: Constipation , often manageable with fiber supplementation and hydration Diarrhea , particularly in the early weeks Bloating and gas Fatigue , especially during initial dose adjustment Injection site reactions including redness or itching Most of these side effects are mild to moderate and resolve within the first 2-4 weeks at any given dose

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Baseline characteristics and treatment effects Baseline cohort characteristics were taken from the FLOW clinical trial for the full FLOW population, as well as for the two subgroups of patients receiving and not receiving SGLT-2 inhibitors at baseline (Supplementary Material, Table S1) [22,23,24]