Titanium c
Most patients begin noticing improvements in pain and function within 2-4 weeks
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including valsartan, may result in deterioration of renal function, including possible acute renal failure
Moshfeghi, A
That dosing schedule is the central feature, and it is also the reason Lilly is leading with alcohol use disorder rather than obesity
On semaglutide, people lost about 15% of their body weight over a little more than a year (Wilding, New England Journal of Medicine, 2021), and tirzepatide, what I take, runs higher than that