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In a Phase 2b study in people with type 2 diabetes and obesity over 54 weeks, treatment with cotadutide at doses of 100-300 g daily improved some non-invasive markers of NAFLD such as transaminase levels, the FIB-4 index, fatty liver disease fibrosis score (NFS) and fatty liver index (FLI) but fatty liver disease was not assessed directly with liver biopsy

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Obes Surg 28:35533558 Bonnet JB et al (2024) Semaglutide 2.4 mg/wk for weight loss in patients with severe obesity and with or without a history of bariatric surgery