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Materials and methods Rat model of soft tissue injury Animal studies and procedures were carried out in accordance with an approved protocol from the Institutional Animal Care and Use Committee (IACUC) at the Fourth Military Medical University (IACUC-20220505)

Numerous preclinical studies have also suggested that tocotrienols might be beneficial in the prevention of chronic diseases (12)

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Additionally, treatment with 10 nM E2, for 7 days, stimulated differentiation to the neuronal lineage, and inhibited differentiation to astrocytes (Zhang et al., 2019)

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The 2006 Ionescu paper documented that pulsatile GH secretion persists even under continuous receptor stimulation, suggesting somatotroph-intrinsic pulsatile release dynamics independent of receptor-binding temporal patterns (PMID 17018654)